School of Medicine - Internal Medicine
My primary training goal is to contribute to hypothesis-driven original clinical research aimed at improving treatment outcomes for people with multidrug-resistant TB. Secondarily, I hope to improve my understanding of how to conduct multisite cohort studies in low-resource settings.
I will assist in data quality control, data entry, and analysis for a prospective observational cohort study in South Africa involving patients with drug-resistant TB being treated with regimens containing bedaquiline and/or linezolid. The study investigates the pharmacokinetics,
pharmacodynamics, and genetic mechanisms of resistance for both drugs, as well as interactions between bedaquiline and antiretroviral therapies. Data sources will range from reported medical histories and symptoms to blood for pharmacokinetic analyses and sputum for mycobacterial smear, culture, and drug-sensitivity testing.
While I will not be directly involved with data collection, one of my main roles during the six weeks will be to work with research staff at several study sites to help improve data quality and how it is inputted for analysis. The sites that I will be working with include the Médecins Sans Frontières TB clinic in Khayelitsha township, Western Cape; and the Jose Pearson TB Hospital in Port Elizabeth, Eastern Cape. I will be served in this role by my detailed knowledge of the study protocol as well as years of experience with smaller clinical and preclinical TB studies, including in South Africa.
When I return, I plan to present on my experience at Johns Hopkins. And my research contributions may lead to co-authorship on peer-reviewed abstracts and/or publications.
Professor Graeme Meintjes, MBChB, PhD, MPH
Institute of Infectious Disease and Molecular Medicine, University of Cape Town
Cape Town, South Africa