I will participate in research nested within the larger HIV and HCC in Uganda (H2U) Consortium based in Kampala, Uganda. This research consortium aims to improve research infrastructure and capacity in Uganda while investigating the epidemiology, mechanisms, and clinical spectrum of HIV associated HCC.  Specifically, I will participate in data collection using of physiologic and epidemiologic variables (eg aflatoxin-related biomarkers, HBV, HCV, and HIV viral loads, HCC tumor marker levels, and elastography) among HIV, HCV, and HBV affected patients and matched controls in local hospitals. Using this and other, previously collected cross-sectional data, I will conduct analyses looking at prevalence of HCC and other liver diseases, conditions and makers associated with increased risk for progression of liver fibrosis or HCC. With these data, the ultimate aim would be to identify markers of high-risk for HCC or advanced fibrosis that could allow early treatment and prevention of HCC and advanced liver fibrosis.