Yohannan, Jithin

Medicine

MD/MPH

Tanzania

Spatial Distribution of Chalmydia Trachomatis in a Hypoendemic Tanzanian Community

Background: In some low prevalence settings, Trachoma may be eliminated with 1-2 rounds of community wide antibiotic coverage (MDA) while in others trachoma elimination takes 3 or more rounds of treatment for elimination. Clustering of infection may lead to persistence and reemergence of infection after MDA. Objectives: To determine if C. Trachomatis infection clusters at the household level in a low prevalence, antibiotic treated village in Kongwa District, Tanzania. Methods: A village in the Kongwa District Tanzania will be selected based on predicted infection prevalence of 5-9%. GPS mapping of all of the households in the village will be performed. Consenting children less than 10 years will be screened clinically for Trachoma and tested for C. Trachomatis infection via ocular swabbing and polymerase chain reaction. Clustering will be detected using k-function analysis in R. The presence of significant clustering of households with children infected with C. Trachomatis will be determined using the difference in kfunctions between infected and non-infected households. Institutional Support: The Kongwa district is a region with multiple trachoma studies underway. I will have support from study personnel for housing, food, transportation, clinical examination, swabbing for trachoma and GPS mapping. We will have support from the Johns Hopkins Chlamydia laboratory to run PCR samples. I will have access to our group biostatistician and faculty familiar with spatial statistics at Bloomberg for support with statistical analysis.

People

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation
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July 2017

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