Tapley, Asa

School of Medicine - Internal Medicine

South Africa

My primary training goal is to contribute to hypothesis-driven original clinical research aimed at improving treatment outcomes for people with multidrug-resistant TB. Secondarily, I hope to improve my understanding of how to conduct multisite cohort studies in low-resource settings.


I will assist in data quality control, data entry, and analysis for a prospective observational cohort study in South Africa involving patients with drug-resistant TB being treated with regimens containing bedaquiline and/or linezolid. The study investigates the pharmacokinetics,
pharmacodynamics, and genetic mechanisms of resistance for both drugs, as well as interactions between bedaquiline and antiretroviral therapies. Data sources will range from reported medical histories and symptoms to blood for pharmacokinetic analyses and sputum for mycobacterial smear, culture, and drug-sensitivity testing.


While I will not be directly involved with data collection, one of my main roles during the six weeks will be to work with research staff at several study sites to help improve data quality and how it is inputted for analysis. The sites that I will be working with include the Médecins Sans Frontières TB clinic in Khayelitsha township, Western Cape; and the Jose Pearson TB Hospital in Port Elizabeth, Eastern Cape. I will be served in this role by my detailed knowledge of the study protocol as well as years of experience with smaller clinical and preclinical TB studies, including in South Africa.


When I return, I plan to present on my experience at Johns Hopkins. And my research contributions may lead to co-authorship on peer-reviewed abstracts and/or publications.

Professor Graeme Meintjes, MBChB, PhD, MPH

Institute of Infectious Disease and Molecular Medicine, University of Cape Town

Cape Town, South Africa

People

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...
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August 2019

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