Surkan, Pamela

Public Health - International Health

Impact of iron and zinc supplementation on development in Nepalese children

Research has shown a link between iron and zinc deficiencies and adverse cognitive and behavioral outcomes. However, data from randomized trials are inconclusive. Recent studies from the Sarlahi district of Nepal indicate that approximately 40% of children are iron deficient and over half have some degree of zinc deficiency. The main objective of our study is t 1) estimate the treatment effects of iron and zinc supplementation on temperament, feeding interactions, and language skills in Nepalese infants. Secondary  objectives are: 2) to identify socio-demographic risk factors for these developmental outcomes, and 3) to estimate associations between parental report versus in-person observations of temperament and feeding interactions in this population. Participants included 569 children ages 4 to 17 months. Infants were randomized to receive daily supplementation of (A) 10 mg zinc, (B) 12.5 mg iron and 50 ?g folic acid, (C) a combination of 10 mg zinc, 12.5 mg iron and 50 ?g folic acid, or (D) a sugar placebo. For our main objective, intention-to-treat and cumulative dose analyses will be performed to estimate the effects of iron and zinc supplementation on infant temperament, quality of feeding interactions, and language development. This study will provide preliminary results for a future R01 application that more carefully examines infant social and cognitive development in Sarlahi beyond the limited number of endpoints already currently available.

Joanne Katz, ScD, Public Health, International Health; James Tielsch, PhD, Public Health, International Health; Laura Murray-Kolb, PhD, Public Health, InternationalHealth

People

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases
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July 2017

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