Shiff, Clive

Public Health - Molecular Microbiology & Immunology

Chronic Urinary Schistosomiasis, the silent carcinogen: developing biomarkers for its detection

Squamous cell carcinoma of the bladder is extremely uncommon in the world, yet in Africa where Schistosoma haematobium is prevalent, this highly invasive and virulent cancer is the most prevalent type of bladder cancer.  This information comes from hospital based studies, but we have no way to determine the extent of the problem in rural communities living in endemic areas. We have attempted to solve this problem by looking for biomarkers which can associate the parasite and the bladder cancer.  In a series of 4 papers already published and one still in review we have examined the role of alterations in nuclear morphometry as well as epigenetic changes in tumor suppressive genes detected in cellular deposits taken from urine specimens. We also developed a new test for active S. haematobium infection by detecting parasite specific DNA in urine, and showing that this can be collected simply by filtering the urine in the field, drying the filter paper and returning it to the laboratory.  We have named the test the “Hamburger-Abbassi” test in honour of the scientists that designed the primers we used in the test.

Robert Veltri

People

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...
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August 2018

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Projects

Nutrition Innovation Lab

"Poshan", which means good nutrition in Nepali is ongoing research that involves two interlinked large-scale research studies...

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Building an Enabling Environment for Vaccines in India...

This project, now in its second phase, aims to create an enabling environment for vaccines in India and contribute to...

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Identification and Enumeration of Pathogens in Drinking...

CWH researchers are using polymerase chain reaction and mass spectrometry technologies to develop a microbial isolation and...

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Mpilonhle

Mpilonhle brings multi-dimensional services to adolescents in rural South Africa. Its objective is to reduce the very high...

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