Maurizio, Paul

Public Health

MSc

Zambia

Detection and characterization of Culex flaviviruses in Zambian Culex quinquefasciatus mosquitoes for cloning and paratransgenesis studies on Wuchereria bancrofti transmission and lymphatic filariasis elimination in Africa

As of 2004 lymphatic filariasis (LF) is known to be endemic in Zambia, as well as 80 other countries worldwide, with 1.3 billion people at risk, including almost 500 million children. Over 120 million people have been affected, and it is the fourth leading cause of permanent disability, including elephantiasis. The World Health Assembly Resolution 50.29 (WHA 50.29) in 1997 determined that LF was a potential candidate for global eradication. Wuchereria bancrofti is an important Culex-borne agent of LF. Over half of all lymphatic filariasis transmission occurs through Culex pipiens complex mosquitoes, including Culex quinquefasciatus. More cost-effective vector control measures for Culex mosquitoes are needed to ensure success of the Global Programme to Eliminate Lymphatic Filariasis (GPELF), established in 2000, and sustainable disease elimination. Paratransgenic disease control, a strategy being proposed for a variety of vector-borne diseases, involves the utilization of genetically modified symbiotic microorganisms of the disease vectors to manipulate their vectorial capacity. This goals of this field project are to carry out adult and larval mosquito field collections, to perform preliminary characterization on a recently identified Culex flavivirus in Zambian Culex mosquitoes, and to explore virus-mediated options for vector and parasite control of LF in Africa.

People

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases
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October 2018

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