Jarrett, Brooke

School of Public Health

MSPH

South Africa

Strategies to increase the uptake of isoniazid preventive therapy in South Africa

TB is the leading killer of people living with HIV worldwide. Isoniazid preventive therapy (IPT) has been well established to drastically reduce the risk of TB in people living with HIV, but fewer than 30% of eligible patients worldwide started IPT in 2014.  This is a pilot project which is a prospective study of strategies to increase IPT uptake within 4 primary health care clinics in a high TB/HIV burden district of South Africa.  Strategies will include: 1) Building patient demand and empowerment through waiting queue education sessions; 2) Interactive training and mentoring of clinicians. Clinics will be matched on HIV-infected patient volume and historical IPT initiation rate. After a two month control period with no intervention, pairs of clinics will be randomly assigned to receive either the patient or clinician education strategies for four months, after which we will continue monitoring IPT initiation for a four month post-intervention period. We will evaluate the effectiveness, durability, patient and clinician acceptability/perceived barriers to uptake, and cost-effectiveness of each strategy.

Global Health Mentor/PI: Colleen Hanrahan, PhD

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October 2020

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