School of Public Health
TEKO - Quantiferon Gold Test for Detecting TB Infection in HIV/AIDS Patients in South Africa
The TEKO study, named for the word "test" in the South African Sesotho language, is a cluster randomized trial in 14 HIV clinics in South Africa comparing time to determine latent TB infection (LTBI) status in patients in clinics using QuantiFERON Gold In-Tube (QGIT) and the tuberculin skin test (TST) versus those with TST only. We linked QGIT with CD4 blood collection and provided an operational comparison between QGIT and TST in HIV-infected patients in a country that accounts for one-third of the HIV-related TB in the world. While patient enrollment and follow up has been completed, the TEKO study data analysis is currently ongoing. Careful evaluation of the implementation and operational aspects of the program will provide useful knowledge for future scale-up in this and other HIV clinic settings.
The TEKO database is currently being used to answer many questions regarding HIV and TB. Ongoing analyses aim to understand QGIT performance and implementation in HIV-infected individuals, as well as determining what current LTBI diagnostic procedures are being used in the local clinics. Additional data is required from the National Health Laboratory Service (NHLS) and the local Tier.net databases. The NHLS is a national database of laboratory results, including those from HIV tests and CD4 / viral load blood collections. Tier.net databases are housed in individual clinics, with monthly reports being provided to the province. These additional data will enhance the power of the TEKO database and answer new emerging questions.
PI Mentor: Jonathan Golub