George, Christine Marie

Public Health - International Health

A Hospital Based Cholera Intervention for Household Contacts of Cholera Cases

Previous studies in Bangladesh have demonstrated that household contacts of cholera cases are at a much higher risk of developing cholera than the general population (200-240/1000 cases vs. 2.5/1000, respectively). However, little work has been done to develop interventions for this high risk population. We hypothesize that providing a cholera prevention package, containing chlorine tablets and a narrow neck water vessel, and delivering communication messages on cholera to cholera cases at the hospital prior to discharge will reduce the incidence of cholera cases among household contacts in comparison to a standard message given at discharge on the proper use of oral rehydration therapy. To test this hypothesis we would like to conduct an intervention study of 172 cholera cases and their corresponding household contacts at hospital discharge in rural Bangladesh: 86 cases will receive a cholera prevention package and 86 cases will receive the standard message. We will compare drinking water collected from these households with regard to the presence of residual chlorine and V. cholerae. We will use this award for a pilot study which will provide preliminary data necessary for a R01 submission for the larger intervention study. Specifically we would like to: (1) conduct the first field based evaluation of the dipstick method for measuring V. cholerae in water; (2) pilot our developed communication materials for cholera; and (3) conduct multilocus variable-number tandem-repeat analysis to examine V. cholerae isolates from environmental samples and cholera cases to determine the transmission routes for cholera infection to household contacts. 

People

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program
«

November 2018

»
S
M
T
W
T
F
S
·
·
·
·
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
·

Projects

Building an Enabling Environment for Vaccines in India...

This project, now in its second phase, aims to create an enabling environment for vaccines in India and contribute to...

Read More

Identification and Enumeration of Pathogens in Drinking...

CWH researchers are using polymerase chain reaction and mass spectrometry technologies to develop a microbial isolation and...

Read More

Nutrition Innovation Lab

"Poshan", which means good nutrition in Nepali is ongoing research that involves two interlinked large-scale research studies...

Read More

Mpilonhle

Mpilonhle brings multi-dimensional services to adolescents in rural South Africa. Its objective is to reduce the very high...

Read More