School of Public Health
Bangladesh - A cluster-randomized controlled trial of safe drinking water
Diarrhea is the second leading cause of death in children under 5 years of age globally . Although there has been extensive progress in the field of water, sanitation, and hygiene (WASH) in decreasing the incidence of diarrheal disease in children [9-11], there have been challenges in sustainability of these interventions and successful implementation in urban, low-resource settings [12, 13]. Our team developed the hospital-based WASH intervention, CHoBI7 (Cholera-Hospital-Based Intervention-for-7-days), to reduce cholera infection among family members of hospitalized cholera cases. Our first CHoBI7 trial led to a significant reduction in cholera. Thus, we are currently executing a second randomized controlled trial (RCT) to evaluate low cost approaches to extend this intervention to household members of all diarrhea patients in health facilities in Dhaka, Bangladesh. This summer, I will conduct a pilot study nested within this larger intervention program with five primary objectives: (1) Supervising the pilot study of the developed clinical and environmental surveillance tools; (2) Developing field and laboratory protocols for sample collection, storage, and analysis; (3) Analyzing quantitative data collected from the field related to intervention uptake, and preparing weekly team reports; (4) Assisting with the development of the digital data capture system to store the data collected from the larger RCT; and (5) Developing the quality control protocol for the clinical and environmental surveillance tools. This work will be critical to the success of the pilot study and for initiating the upcoming RCT. These data and protocols will be used for my dissertation research and informing the next stages of scaling up our CHoBI7 intervention in September 2016.
Global Health Project Grant Advisor/Mentor: Christine Marie George, PhD