Innate immunity to respiratory pathogens in Influenza-immunized children: A pilot study

Dates

Start Date: 01/03/2011
End Date: 12/31/2011

The pathophysiology of pneumonia and immune regulation of the inflammatory response to lung infections are poorly understood, and only few of the factors causing severe disease or death have been identified. In pneumonia research, acquired immunity has received considerable attention but the role of innate immunity, particularly related to severe childhood pneumonia, has not. However, there is considerable evidence that the innate immune response upon infection in the respiratory tract is involved in the severity of disease outcome. The pathophysiology of pneumonia and immune regulation of the inflammatory response to lung infections are poorly understood, and only few of the factors causing severe disease or death have been identified [1]. In pneumonia research, acquired immunity has received considerable attention but the role of innate immunity, particularly related to severe childhood pneumonia, has not. However, there is considerable evidence that the innate immune response upon infection in the respiratory tract is involved in the severity of disease outcome. We are currently investigating the impact of influenza immunisation (TIV vaccine) of young children on the incidence of pneumonia and its transmission to house-hold members (non-vaccinees) in an urban slum in Dhaka, Bangladesh (PR-09054). One of the aims of this study is to describe the impact of vaccination on non-laboratory-confirmed syndromic outcomes, including influenza like illness (ILI), febrile respiratory illness and pneumonia. Influenza immunisation not only protects against subsequent influenza infection but might also modify the immune response to any subsequent infection and thus influence the disease outcome of this infection. We therefore are investigating the innate immune response to any respiratory infection after TIV vaccination in young children, and comparing the responses of children developing severe pneumonia with those who do not among both TIV-vaccinated and placebo controlled children. This study will be embedded in the larger Influenza vaccine pneumonia trial, using the same study population and logistics. The goal of the present study will be to identify innate immune correlates of childhood pneumonia. Because only limited data are available on the lung's innate immune response in humans, we propose to start with a pilot study to explore the ability to measure parameters of the innate immune response in specimens that we are able to obtain from young children. If successful this pilot study will serve as proof concept for a larger study on innate immunity and pneumonia and its severity. The purpose of that larger study will be to identify potential points of therapeutic and/or preventive intervention in childhood pneumonia.

People

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...
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December 2019

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