Impact of Umbilical Cord Cleansing with Chlorhexidine on Neonatal Mortality and Omphalitis in Bangl

Dates

Start Date: 10/01/2006
End Date: 09/30/2011

This two-phase study will evaluate the impact of umbilical cord cleansing with chlorhexidine in Sylhet District, Bangladesh. The design and methods for this study will build upon the already existing infrastructure and capacity of personnel currently working in Projahnmo, thus providing considerable cost savings. The first phase of this project will entail two distinct activities: a) scaling up of essential newborn care activities currently being evaluated to the entire Sylhet trial areas including the current comparison clusters and b) formative research to develop strategies to deliver the new intervention (chlorhexidine cleansing of the umbilical cord). The implementation of the essential newborn care program will form the foundation upon which the proposed chlorhexidine trial will be conducted. The formative research on chlorhexidine cleansing of the cord will provide information crucial for implementation of the second phase of the study. In order to move toward a delivery model based on minimally trained community health workers, several outstanding issues must be explored. Combining this contextual understanding with family members' attitudes towards incorporation of chlorhexidine cleansing of the cord and exploration of various potential formulations of chlorhexidine will allow development of appropriate behavior change messages that will support the compliance with the intervention in phase II. Furthermore, different models for packaging and delivery of chlorhexidine for routine implementation must also be explored. In Phase II, the Intervention Trial, the study has been designed as a community-based, double-masked, cluster-randomized trial. The two primary outcomes of this trial will be neonatal mortality and omphalitis among live born infants.

Zanzibar, Tanzania, United Republic of
Sylhet, Bulgaria

People

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases
«

September 2018

»
S
M
T
W
T
F
S
·
·
·
·
·
·
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
·
·
·
·
·
·

Projects

Mpilonhle

Mpilonhle brings multi-dimensional services to adolescents in rural South Africa. Its objective is to reduce the very high...

Read More

Nutrition Innovation Lab

"Poshan", which means good nutrition in Nepali is ongoing research that involves two interlinked large-scale research studies...

Read More

Identification and Enumeration of Pathogens in Drinking...

CWH researchers are using polymerase chain reaction and mass spectrometry technologies to develop a microbial isolation and...

Read More

Building an Enabling Environment for Vaccines in India...

This project, now in its second phase, aims to create an enabling environment for vaccines in India and contribute to...

Read More