Isabelle Coppens, PhD MSc


Molecular Microbiology and Immunology, Bloomberg School of Public Health

SciVal Website Link
Current Courses Link

Toxoplasma,Plasmodium liver stage,Cryptosporidium,host cell-parasite interactions,parasitophorous vacuole,nutrient uptake,lipids,cholesterol,cytoskeleton,cell biology,drug targeting,

  • -Pszenny V, Ehrenman K, Romano JD, Kennard A, Schultz A, Roos DS, Grigg ME, Carruthers VB and Coppens I (2015) A lipolytic Lecithin:Cholesterol Acyltransferase secreted by Toxoplasma facilitates parasite replication and egress. J. Biol. Chem., in press.

    -Nolan SJ, Romano JD, Luechtefeld T and Coppens I (2015) Neospora caninum recruits host cell structures to its parasitophorous vacuole and salvages lipids from organelles. Eukaryot. Cell 14:454-473.

    -Jayabalasingham B, Voss C, Ehrenman K, Romano JD, Smith ME, Fidock DA, Bosch J and Coppens I (2014) Characterization of the Atg8-conjugation system in two Plasmodium parasites with special focus on the liver stage: Possible linkage between the apicoplastic and autophagic systems? Autophagy 10:269-284.

    -Coppens I (2014) Exploitation of auxotrophies and metabolic defects in Toxoplasma as therapeutic approaches. Int. J. Parasitol. 44:109-120.

    -Coppens I (2013) Targeting lipid biosynthesis and salvage in apicomplexan parasites for improved chemotherapies. Nat. Rev. Microbiol. 11:823-835.

    - Romano J, Sonda S, Bergbower E, Smith ME and Coppens I (2013) Toxoplasma gondii salvages sphingolipids from the host Golgi through the rerouting of selected Rab vesicles to the parasitophorous vacuole. Mol. Biol. Cell 24:1974-1995.

    - Lige B, Sampels V and Coppens I (2013) Characterization of a second sterol-esterifying enzyme in Toxoplasma highlights the importance of cholesterol storage pathways for the parasite. Mol. Microbiol. 87:951-967.

    - Ehrenman K, Wanyiri JW, Bhat N, Ward HD and Coppens I (2013) Cryptosporidium parvum scavenges LDL-derived cholesterol and micellar cholesterol internalized into enterocytes.  Cell. Microbiol. 15:1182-1197.

    - Romano JD, de Beaumont C, Carrasco JA, Ehrenman K, Bavoil PM and Coppens I (2013) Fierce competition between Toxoplasma and Chlamydia for host cell structures in dually infected cells. Eukaryot. Cell 12:265-277.

    - Romano JD, de Beaumont C, Carrasco JA, Ehrenman K, Bavoil PM and Coppens I (2012) A novel co-infection model with Toxoplasma and Chlamydia trachomatis highlights the importance of host cell manipulation for nutrient scavenging. Cell. Microbiol. 15:619-646.

     - Lige B, Romano JD, Bandaru VV, Ehrenman K, Levitskaya J, Sampels V, Haughey NJ and Coppens I (2011) Deficiency of a Niemann-Pick, type C1-related protein in Toxoplasma is associated with multiple lipidoses and increased pathogenicity. PLoS Pathog. 7:e1002410.

    - Labaied M, Jayabalasingham B, Bano N, Cha SJ, Sandoval J, Guan G and Coppens I (2011) Plasmodium salvages cholesterol internalized by LDL and synthesized de novo in the liver. Cell. Microbiol. 13:569-586.

    -Ehrenman K, Sehgal A, Lige B, Stedman TT, Joiner KA and Coppens I (2010) Novel  roles  for  ATP-binding  cassette  G  transporters  in  lipid  redistribution  in Toxoplasma. Mol. Microbiol. 76:1232-1249.

    -Jayabalasingham B, Bano N and Coppens I (2010) Metamorphosis of the malaria parasite in the liver is associated with organelle clearance. Cell Res. 20:1043-1059.

    -Lige B, Jayabalasingham B, Zhang H, Pypaert M and Coppens I (2009) Role of an ancestral D-bifunctional protein containing two sterol-carrier protein-2 domains in lipid uptake and trafficking in Toxoplasma. Mol. Biol. Cell. 20:658-672.

    -Romano JD, Bano N and Coppens I (2008) New host nuclear functions are not required for the modifications of the parasitophorous vacuole of Toxoplasma. Cell. Microbiol. 10:465-476.

    -Bano N, Romano JD, Jayabalasingham B and Coppens I (2007) Cellular interactions of Plasmodium liver stage with its host mammalian cell. Int. J. Parasitol. 37:1329-1341.

    -Coppens I, Dunn JD, Romano JD, Pypaert M, Zhang H, Boothrod JC and Joiner KA (2006) Toxoplasma sequesters host lysosomes in the vacuolar space. Cell 125:261-274.

    -Sehgal A, Bettiol S, Wenk MR, Pypaert M, Kaasch A, Blader I, Joiner KA and Coppens I (2005) Peculiarities of host cholesterol transport to the unique intracellular compartment containing Toxoplasma gondii. Traffic 6:1-17.

    -Nishikawa N, Quittnat F, Stedman TT, Voelker DR, Choi JY, Zahn M, Yang M, Joiner KA and Coppens I (2005) Host cell lipids control cholesteryl ester synthesis and storage in intracellular Toxoplasma. Cell. Microbiol. 7:849-867.

    -Quittnat F, Nishikawa Y, Stedman TT, Voelker DR, Choi JY, Zahn M, Murphy R, Martin W, Yang M, Joiner KA and Coppens I (2004) Synthesis of triacylglycerols in an ancient eukaryote: Identification and functional expression of a Toxoplasma DGAT1-related enzyme. Mol. Biochem. Parasitol. 138:107-122.

    -Coppens I and Joiner KA (2003) Host but not parasite cholesterol controls Toxoplasma cell entry by modulating organelle discharge. Mol. Biol. Cell 14:3804-3820.

    -Coppens I, Sinai AP and Joiner KA (2000) Toxoplasma gondii exploits host low-density lipoprotein receptor-mediated endocytosis for cholesterol acquisition. J. Cell Biol. 149:167-180.


Yukari C. Manabe, MD

Associate Director of Global Health Research and Innovation

Robert Bollinger Jr., MD MPH

Director, Johns Hopkins Center for Clinical Global Health Education (CCGHE); Associate Director, Johns Hopkins Center for Global...

Stefan Baral, MD MPH,MBA,MSc

Director, Key Populations Program

Noreen Hynes, MD MPH

Director, Geographic Medicine Center of the Division of Infectious Diseases

Joanne Katz, ScD MS,BSc

Associate Chair, Director of Academic Programs

Caitlin Kennedy, PhD MPH,BA

Co-Director, MPH concentration in Social and Behavioral Sciences in Public Health; Associate Director, Center for Qualitative...

March 2020



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